Barrett's esophagus (BE), a condition of intestinal metaplasia of the esophagus, develops as a consequence of chronic gastroesophageal reflux disease and is associated with an increased risk of esophageal adenocarcinoma. Traditionally, high-grade dysplasia and intramucosal cancer arising from BE were treated with esophagectomy, while non-dysplastic BE and BE with low-grade dysplasia were managed with endoscopic surveillance. Problems associated with these approaches included significant morbidity and mortality from esophagectomy, and the risk of missed or interval development of cancer in patients undergoing surveillance. To address these issues, less invasive endoscopic treatments have been developed.

This topic will review the use of endoscopic treatments of Barrett's esophagus.